IVIVC / IVIVR
In Vitro–In Vivo Correlation
Investigate relationships between in-vitro performance and in-vivo response.
Overview
IVIVC and related in-vitro–in-vivo approaches evaluate how laboratory measurements may relate to in-vivo drug behavior, subject to data suitability.
Each modeling strategy must be tailored to the available data, scientific question and applicable regulatory expectations.
Potential applications
- Dissolution–exposure relationship assessment
- Formulation change evaluation
- Predictive performance investigation
Illustrative outputs
- Data suitability review
- Correlation development and evaluation
- Scientific documentation
Discuss a specific development question
We can start by defining the scientific objective and available evidence.