PBBM
Physiologically Based Biopharmaceutics Modeling
Connect formulation performance, dissolution and systemic exposure.
Overview
PBBM combines biopharmaceutic information and mechanistic models to evaluate how formulation and dissolution behavior may affect pharmacokinetics.
Each modeling strategy must be tailored to the available data, scientific question and applicable regulatory expectations.
Potential applications
- Formulation and dissolution risk assessment
- Critical material and process attribute exploration
- Biopharmaceutic scenario evaluation
Illustrative outputs
- Data gap assessment
- Model development and qualification plan
- Scenario analyses and scientific report
Discuss a specific development question
We can start by defining the scientific objective and available evidence.