PBPK
Physiologically Based Pharmacokinetic Modeling
Mechanistic simulation of drug exposure across physiological scenarios.
Overview
PBPK integrates drug properties, formulation characteristics and physiology to investigate exposure and inform development decisions.
Each modeling strategy must be tailored to the available data, scientific question and applicable regulatory expectations.
Potential applications
- Exposure predictions across populations and conditions
- Drug–drug interaction and sensitivity assessments
- Model-informed development planning
Illustrative outputs
- Model strategy and assumptions
- Simulation scenarios and interpretation
- Technical reporting aligned with agreed scope
Discuss a specific development question
We can start by defining the scientific objective and available evidence.